MYC and cancer: Interestingly, phase separation of MYC occurs in unperturbed cancer cells (i.e., cancer cells under normal growth conditions without external stressors) and is enhanced under various stress conditions, including proteasomal inhibition, perturbation of transcription elongation, mRNA splicing, and upon exposure to heat shock, suggesting that MYC phase separation is able to alleviate the perturbation caused by these stressors [26].