COA8 and infection: Infection of macrophages with E. chaffeensis triggered elevated expression of mitochondrial-associated genes such as san (N-(alpha) acetyltransferase 50), Cht11 (chitinase 11), Uck2 (uridine/cytidine kinase), Echs1 (enoyl-CoA hydratase), whd (carnitine palmitoyl transferase 1), Ccdc58 (coiled-coil domain-containing protein 58), and Apop1 (apoptogenic 1) in infected macrophages (20).