Therefore, the objective of this study was to assess the patterns of gene expression of CotH3, GPR78, and their target miRNAs (hsa-miR-16–5p, hsa-miR-93–3p, hsa-miR-335–5p, and mmu-miR-181b-5p) during infection in macrophages derived from human monocytes (monocyte-derived macrophages [MDMs]), renal tissue of diabetic BALB/c mice infected with R. oryzae, with and without treatment with liposomal amphotericin B (LAmB), as well as in sinus tissue from patients with mucormycosis. The gene discussed is GPR78; the disease is infection.