Previous studies have found that infection with C. parvum, T. gondii, and N. caninum could activate the NF-κB signaling pathway of host cells (31, 51, 52), but only C. parvum infection specifically downregulated the expression of BACE1-AS in host cells by triggering the NF-κB signaling pathway in the present study. This evidence concerns the gene NFKB1 and infection.