Overall, patients at NAC stage III tended to be older (mean age [standard deviation, SD]: 78.0 [6.1] years) vs. stage II (75.0 [6.3] years) and stage I (72.7 [7.4] years), more likely female (19% vs. 7% and 10%), with a variant TTR genotype (34% vs. 19% and 24%), and with NYHA class III HF (57% vs. 36% and 19%). The gene discussed is TTR; the disease is hydrops fetalis.