Among these, β2AR is the main subtype found in human innate immune cells.[37, 38] Sympathetic signaling has been reported to regulate lymphocyte dynamics and regulate adaptive immune responses through β2ARs.[29, 30] To explore whether sympathetic neurotransmitters promote EBV+ DLBCL growth through β2ARs or β3ARs, we pre‐treated human DLBCL cell lines (SUDHL4 and SUDHL6), the EBV‐positive cell line Farage, and EBV‐infected cell lines (SUDHL4‐EBV and SUDHL6‐EBV) with selective antagonists: ICI‐118551 (β2AR blocker) and SR59230A (β3AR blocker). The gene discussed is ADRB3; the disease is diffuse large B-cell lymphoma.