ADRB2 and diffuse large B-cell lymphoma: Notably, in The Cancer Genome Atlas (TCGA) database, high mRNA expression levels of ADRB2 (which encodes β2AR) were significantly correlated with shorter OS in DLBCL patients, as shown in Figure 7G, generated using the OSDLBCL online analysis platform.[39] Taken together, these findings demonstrate that EBV+ DLBCL tumors exhibit increased infiltration of sympathetic nerves, which is associated with poor survival.