BDNF, a well‐characterized neurotrophin, stimulates axonal elongation and branching through activation of its receptor TrkB and downstream PI3K/Akt and MAPK signaling pathways.[47, 48] Similarly, SEMA7A, originally identified as an immune modulator, promotes neurite outgrowth by binding to integrins and activating MAPK signaling.[49] PLXNB2 serves as a receptor for semaphorins.[50, 51] Their upregulation suggests that EBV+ DLBCL tumors may promote sympathetic nerve innervation by releasing axon guidance factors. Here, AKT1 is linked to diffuse large B-cell lymphoma.