TYK2 and cancer: 79), while PUS7 overexpression correlates with poor prognosis in patients with glioblastoma (GBM) by enhancing tyrosine kinase 2 (TYK2) translation efficiency of via tRNA pseudouridylation (Figure 1h), thereby promoting glioblastoma stem cell (GSC) growth (Ref. 81). The dyskerin pseudouridine synthase 1 (DKC1) gene encodes a dyskerin protein with PUS activity, which binds to and catalyzes the uridine isomerization of target RNAs to Ψ. Cancer progression and poor prognosis are linked to the overexpression of DKC1, which has been detected in a range of cancer types (Ref. 6, 82).