37). Oncogenic piR-823 enhances DNA methylation in multiple myeloma (MM) (Ref. 38), while piRNA-14633 drives cervical cancer (CC) via the methyltransferase-like protein 14 (METTL14)/CYP1B1 signaling axis (Ref. 39). Tumor-suppressive piR-39980 targets ribonucleotide reductase subunit M2 (RRM2) (Ref. 40), and piR-36712 downregulation results in elevated selenoprotein W pseudogene 1 (SEPW1), which may inhibit p53, upregulating Slug to promote cell proliferation, invasion, and migration (Ref. 41). Here, METTL14 is linked to Miyoshi myopathy.