AKT1 and early-onset autosomal dominant Alzheimer disease: Notably, the four metabolites orchestrate multi‐target regulation of the PI3K–Akt signaling pathway, Alzheimer's disease‐related cascades, and neurodegeneration networks (Figure 15), aligning with prior evidence of KWG's neuroprotection via PI3K/Akt/GSK3αβ modulation (Gan et al. 2021) and broader recognition of natural products targeting this axis (Wang and Zhao 2016; Cui et al. 2022).