However, the hydrophobicinteractions of the triterpene moiety were not negligible and occurredin over 75% of the cases, especially for compound 1.In our study, the activity of compounds 1 and 2 as LIFR antagonists was confirmed by in vitro evaluation.The two compounds indeed showed to reduce hepatic stellate cells activationand collagen deposition, highlighting their antifibrotic action andthe potential role of these bioactive metabolites of Boswellia extracts on liver fibrosis therapy. This evidence concerns the gene LIFR and Hepatic fibrosis.