In the context of cancer, KLF4 regulates several malignancies, including lung cancer, colon cancer, hepatocellular carcinoma, and meningiomas (Tsytsykova et al. 2022, Chen et al. 2023, He et al. 2023, Zheng et al. 2023). The gene discussed is KLF4; the disease is malignant colon neoplasm.