CCND2 and keloid: MR analysis revealed that CCND2 is causally associated with keloid [inverse variance weighted (IVW) odds ratio (OR): 1.410; 95% confidence interval (CI): 1.001–1.985, P = .049], indicating it is a risk factor, while KLF4 is inversely associated with keloid (IVW OR: 0.492; 95% CI: 0.290–0.835, P = .009).