Both HAE due to C1 inhibitor (C1INH) deficiency (HAE-C1INH) type 1 (HAE-C1INH-Type1) and type 2 (HAE-C1INH-Type2) are associated with mutations in the SERPING1 gene coding for C1INH.1 The gene discussed is SERPING1; the disease is hereditary angioedema.