PTPA and multiple sclerosis: Compelling evidence has revealed a strong correlation between PP2A dysfunction and a range of diseases commonly observed in individuals with hypoxia, including pulmonary arterial hypertension (Naeije et al., 2022), multiple sclerosis (Ho et al., 2012), inflammation (Eltzschig and Carmeliet, 2011), and cancer (Shi et al., 2019).