Increasing evidence has shown that Astragalus membranaceus and its main chemical components, such as formononetin, hederagenin, and calycosin, could prevent and treat renal diseases, including DKD, by inhibiting endoplasmic reticulum stress, mitochondrial damage, long non-coding RNA A330074k22Rik/Axin2/β-catenin signaling pathway and ferroptosis (23–27). This evidence concerns the gene AXIN2 and kidney disorder.