Single‐cell RNA‐seq of COPD lungs (GSE17389632) revealed cell type‐specific inflammatory signatures: fibroblasts (adventitial/alveolar) showed elevated CCL‐2, IL‐6, and ICAM‐1, whereas neutrophils/myofibroblasts/macrophages upregulated CXCL‐3/8/10, TNF‐α, and CCL‐7 (Figure S12A,B). Here, ICAM1 is linked to chronic obstructive pulmonary disease.