IL6 and chronic obstructive pulmonary disease: Two‐sample MR analysis using IL6‐AS1‐associated SNPs as IVs (120 lung tissue [GTExv8]; 56 whole blood [eQTLGen]) revealed causal associations with COPD outcomes. For COPD diagnosis, inverse variance weighted (IVW) analysis demonstrated significant positive correlations without heterogeneity or pleiotropy using MR‐PRESSO (Figures 8C and S22A and Tables S8–10).