In addition, we found that the metabolic panel exhibited significantly superior performance (AUC = 0.900, 95% CI: 0.857–0.943; sensitivity: 75.0%, specificity: 91.3%) in discriminating CRC from NC compared to CEA (AUC = 0.773, 95% CI: 0.705–0.841; sensitivity: 67.4%, specificity: 76.1%) (DeLong test, p = 0.003) (Figure 5). Here, CEACAM5 is linked to colorectal carcinoma.