EGF and neoplasm: In this experiment, the mice injected with G12V + EGF culture cells exhibited greater tumor area than the injected with G12V or WT + EGF culture cells only at 7 weeks post-injection (Fig. 5H), although there was a marked difference in the rate of total fluorescence signal development among these groups (G12V + KRAS > KRAS > EGF), indicating G12V and EGF treatment had synergistic effects to promote tumor growth, with the combination of both inducing a rapid increase in cancer cell expansion.