The hepatitis B virus (HBV) X protein (HBX reduced GDH1 protein stability by promoting its ubiquitination, mediated by LIM and SH3 protein 1 (LASP1) and E3 ubiquitin ligase synoviolin (SYVN1), indicating the possible role of GDH1 in contributing to HBV-induced HCC.189. The gene discussed is LASP1; the disease is hepatocellular carcinoma.