Mechanistic investigations identified three active ingredients of XBJ including scutellarin, salvianolic acid C, and isosalvianolic acid C, as potential modulators of MMP9 and TLR4, suggesting the role of XBJ in attenuating inflammatory responses and improving infection outcomes.<h4>Conclusion</h4>XBJ appears effective and safe as an adjuvant therapy for <i>A. This evidence concerns the gene TLR4 and infection.