The regulation of DPYSL2 is closely associated with the mTOR signaling pathway, which is known to promote cell growth and division (Miloslavski et al., 2014; Patursky-Polischuk et al., 2009), regulate macrophage polarization (Guertin and Sabatini, 2007; Efeyan and Sabatini, 2010), and is widely implicated in cancer biology. The gene discussed is DPYSL2; the disease is cancer.