Apoptosis mediated by the Fas/Fas ligand (FasL) pathway is one of the mechanisms involved in the pathogenesis of NAFLD, and the ROS-induced binding of FasL to the Fas receptor (FasR) in hepatocytes triggers apoptosis, which activates Kupffer cells and hepatic stellate cells (HSCs) and promotes hepatic fibrosis (Lin et al., 2013). This evidence concerns the gene FASLG and metabolic dysfunction-associated steatotic liver disease.