Moreover, geniposide reduces fatty acid and sterol synthesis, ameliorates oxidative stress and alleviates NAFLD by upregulating Nrf2 expression and regulating the protein expression of components of the AMPK/PI3K/mammalian target of rapamycin (mTOR) signaling pathway, inhibiting the phosphorylation of mTORC and its related proteins and modulating the expression of sterol regulatory element binding protein-1c (SREBP-1c) (Shen et al., 2020). The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatotic liver disease.