IL6 and muscle atrophy: With regard to other models of skeletal muscle atrophy, HET has been reported to improve muscle atrophy by suppressing Atrogin-1 and activating AMPK in a disuse-induced muscle atrophy model (Yakabe et al., 2022), by suppressing IL-6 production in colon 26 adenocarcinoma (Yae et al., 2012), and inhibiting inflammation and oxidative stress in an amyotrophic lateral sclerosis mouse model (Cai and Yang, 2019).