MESP1 and gastric cancer: Additionally, other studies have claimed that Diosgenin can resist the proliferation and invasion of GC cells in a low-oxygen environment (Mao et al., 2012), and also inhibit the proliferation of GC cells by suppressing the expression of MESP1 (Gu et al., 2021) and regulating the expression of cell adhesion molecules (Mao et al., 2012) in GC cells.