AKT1 and osteosarcoma: A study also showed that FA could reduce proliferation in 143B and MG63 osteosarcoma cells in vitro at a concentration of 10–150 μM and MG63 xenograft model in mice in vivo at a concentration of 100 mg/kg by inducing apoptosis and reducing CDK 2, 4, and 6, PI3K/AKT pathway [134].