A study by Chen et al. [119] also found that FA extensively plays a vital role in inducing autophagy and apoptosis of colon cancer CT-26 cells at a concentration of 800 μM and BALB/c mice via increasing ERK, JNK, cytotoxicity, Bax and decreasing Bcl-2, NF-κB, and TNF-α [119]. This evidence concerns the gene MAPK8 and malignant colon neoplasm.