AKT1 and lung cancer: It also found that FA derivative FXS-3 showed inhibition in proliferation of lung cancer A549 cells in vitro and xenograft mouse model in male BALB/C nude mice (A549 cells) in vivo (n = 8) by promoting JNK signaling pathway and negatively controlling ERK/p38, AKT/mTOR, and MEK/ERK signaling pathways, which showed essential scientific foundation for the development of anticancer medication about FA derivatives [123].