CASP3 and lung cancer: A study by Bandugula and Rajendra Prasad showed that the combination of 2DG and FA could induce efficacy of anticancer activity by increasing the expression of p21, p53, Bax, GADD45A, and caspase-3, which caused cell death, cytotoxicity, and cell cycle arrest in lung cancer cells (NCI-H460) and also suppressed the expression of NF-κB [166].