In conclusion, together with published results from studies of other IL-1 inhibitors, the limited amelioration in the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score and the lack of synovitis improvement may indicate that most individuals with knee OA and synovitis do not benefit from IL-1 inhibition as an analgesic or anti-inflammatory medication.52 This evidence concerns the gene IL1A and arthritic joint disease.