Using the ClinGen gene curation framework, definitive disease genes for CPVT are RYR2, CASQ2, TECRL and TRDN[32] where genes with a moderate evidence for disease causation in CPVT were the three calmodulin genes (CALM1, CALM2, CALM3), TRDN (triadin) and trans-2,3-enoyl-CoA reductase-like gene (TECRL). The gene discussed is CALM3; the disease is catecholaminergic polymorphic ventricular tachycardia.