In 2014, a deletion of exon 3 of RYR2 was reported, associated with left ventricular non-compaction (LVNC); a second report a non-synonymous variant with familial cosegregation showed an unexpected clinical overlap between LVNC and atypical CPVT due to an in-vitro loss-of-function [33]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.