RYR2 and catecholaminergic polymorphic ventricular tachycardia: The majority of CPVT cases (variant sensitivity, 50–60 %) were caused by heterozygous, non-synonymous pathogenic variants in the RYR2 gene (ryanodine receptor 2, CPVT1)[29] that encodes the sarcoplasmic reticulum (SR) Ca2+ channel called ryanodine receptor because of its affinity for binding the alkaloid ryanodine.