In the study of Chiang et al. (38), on Epstein–Barr virus (EBV)-associated lymphoepithelioma-like cholangiocarcinoma (EBV-LELCC) cases as a rare type of iCCA, found that the tumor immune microenvironment (TIME) demonstrates increased Th1 cells, NK CD56 cells, and M1 macrophages, which are associated with longer survival. Here, NCAM1 is linked to cholangiocarcinoma.