The absence of ANXA2 affects tissue-type plasminogen activator (tPA)-dependent plasmin generation on endothelial cell surfaces, which may contribute to cerebral venous thrombosis and systemic lupus erythematosus, leading to thrombus formation (Ao et al., 2011; Cesarman-Maus et al., 2011; Fassel et al., 2021). This evidence concerns the gene PLAT and systemic lupus erythematosus.