However, contradicting findings have been reported in other studies, where the A allele was found to be more prevalent in patients with active disease, and individuals who were IFN-γ (+874) AA homozygous had an increased risk of developing tuberculosis (Álvarez et al., 2023; Adane et al., 2021; Araujo et al., 2017). The gene discussed is IFNG; the disease is tuberculosis.