Another study showed that EVs produced by bone marrow-derived cells in a lung cancer murine model contain miR-92, which also through TGF-β signaling activation in liver stellate cells, induced the production of collagen type I. Thus, miR-92 transferred via EVs to liver stellate cells decreased SMAD2 expression and activated TGF-β signaling, promoting rapid liver metastasis development [100]. The gene discussed is TGFB1; the disease is lung cancer.