INS and diabetes mellitus: Then, after adding diabetes duration, SBP, TG, HDL-C, and LDL-C (Model 2) or diabetes duration, SBP, TG, HDL-C, LDL-C, smoking status, use of insulin therapy, and HbA1c (Model 3) as a confounding factor, the TIR was still an independent risk factor for CAD (Table 3).