Tmem175 was initially reported as an endolysosomal potassium channel.10 However, a recent study suggests that Tmem175 is a proton-activated proton channel on the lysosomal membrane.51 Tmem175 is a genetic risk factor for Parkinson disease.26,56 However, both positive and negative contribution to Parkinson disease has been reported.58,104 Although a role of Tmem175 in pain has not been reported, Tmem175 is associated with neuroinflammation and other types of neurological diseases.79,94,154,160. This evidence concerns the gene TMEM175 and nervous system disorder.