LYST and Chediak-Higashi syndrome: Chediak-Higashi syndrome (CHS) is an autosomal recessive disorder caused by mutations in the Lysosomal Trafficking Regulator (LYST) gene, which lead to a broad range of clinical manifestations associated with the enlargement of lysosomes and LROs, including MC SGs (Turner et al., 2024; Shiflett et al., 2002; Kiyoi et al., 2019).