In certain breast cancer studies, the interaction between ER signaling and the Hippo pathway has been preliminarily elucidated: activation of ERα can indirectly inhibit LATS1/2 activity via upregulation of the PI3K/AKT pathway, thereby promoting the dephosphorylation and nuclear accumulation of YAP/TAZ (Klinge, 2001; Filardo et al., 2000). This evidence concerns the gene ESR1 and breast cancer.