In head and neck cancer, RASSF family members are frequently inactivated due to promoter methylation or gene mutations, a loss of function that is closely associated with decreased MST1/2 activity and aberrant activation of YAP/TAZ, ultimately leading to uncontrolled cell proliferation and tumor metastasis (Dhanaraman et al., 2020; Iwasa et al., 2015). Here, WWTR1 is linked to head and neck cancer.