Functionally, overexpression of YAP1 in HNSCC cell lines (FaDu, SCC-25) markedly enhances proliferation, migration, and cisplatin resistance, whereas knockdown of YAP1 or TAZ restores drug sensitivity and induces apoptosis (Moya and Halder, 2019; Boggiano et al., 2011) (Moya and Halder, 2019; Boggiano et al., 2011). This evidence concerns the gene WWTR1 and head and neck squamous cell carcinoma.