YAP1 and neoplasm: For example, VGLL4, a downstream transcriptional co-regulator within the non-classical Hippo pathway, competitively binds TEAD, thereby not only inhibiting YAP/TAZ-mediated gene expression but also synergistically suppressing Wnt/β-catenin signaling, which in turn impedes tumor cell proliferation and metastasis (Jiao et al., 2017).