Elevated ΔNp63 expression, regulated via non-canonical interactions with polarity and junctional proteins (e.g., AMOT, ZO-1/2), associates with cancer stem-like properties, EMT and drug resistance, and the ΔNp63/YAP ratio enables molecular subtyping and risk stratification (Low-Calle et al., 2023; Fallahi et al., 2016). The gene discussed is AMOT; the disease is cancer.