YAP1 and head and neck squamous cell carcinoma: Accumulating data indicate distinct YAP/TAZ activation patterns in head and neck squamous cell carcinoma (HNSCC) subtypes, with frequent nuclear accumulation of YAP/TAZ correlating with poor prognosis and notably higher activity observed in HPV-negative cases (Faraji et al., 2022; Zamuner et al., 2024).