Aberrant nuclear localization of YAP/TAZ—often driven by high-frequency genomic events such as FAT1 loss, WWTR1 amplification and YAP1 amplification—correlates with increased tumor proliferation, metastasis, chemoresistance and significantly shorter overall and progression-free survival (Faraji et al., 2022; Zhao et al., 2007; Yu et al., 2015). This evidence concerns the gene WWTR1 and neoplasm.