WWTR1 and head and neck squamous cell carcinoma: In head and neck squamous cell carcinoma, reduced expression of AMOT family proteins (such as AMOTL2) decreases their recruitment and stabilization of LATS1/2 kinases, thereby enhancing YAP nuclear translocation by suppressing LATS-dependent YAP phosphorylation (Zou et al., 2024), which is closely associated with YAP/TAZ nuclear accumulation and activation of oncogenic genes (An et al., 2023).