Furthermore, in oral squamous cell carcinoma, downregulation of LATS1/2 expression is closely associated with enhanced nuclear localization of YAP/TAZ, and MAP4K family kinases may act as alternative kinases in this context, maintaining partial Hippo signaling that affects tumor stem cell self-renewal and metastasis (Faraji et al., 2022). The gene discussed is YAP1; the disease is neoplasm.