Given the established importance of glycolytic activity in GCs for oocyte development (Richani et al., 2021) and the reported glycolytic impairment in the GCs of PCOS (Zhang et al., 2022), we subsequently examined the expression of key glycolytic regulators, including HK2, LDHA and PKM2 (Patsoukis et al., 2015). The gene discussed is PKM; the disease is polycystic ovary syndrome.