Recent investigations have identified several TrxR1 inhibitors, particularly metal-containing compounds such as gold(I) NHC complexes, which exert antiproliferative effects on multiple types of cancer cells (Reddy et al., 2018; Karaca et al., 2017; Wang et al., 2024a; Wang et al., 2024b). The gene discussed is TXNRD1; the disease is cancer.