SERPINH1 and cancer: TheSERPINH1gene, which encodes the heat-inducible protein HSP47, is situated on chromosome 11q13.5, a genomic hotspot commonly amplified in various human cancers.69Moreover, data from the University of ALabama at Birmingham CANcer (UALCAN) cancer database reveal that HSP47 mRNA levels are significantly elevated in multiple tumor types, including bladder, breast, colon, liver, lung, and stomach cancers, compared with normal tissues.