Highly expressed CD24 competitively binds to ADP-ribosylation factor 6(Arf6) with G protein-coupled receptor kinase-interactor 2(GIT2) and stabilizes Arf6-GTP to activate subsequent ERK pathways, thereby significantly promoting tumor metastasis and 5-FU chemoresistance [89] (Fig. 3D). This evidence concerns the gene ARF6 and neoplasm.