Immunohistochemical staining revealed that the expression of FOXM1, Ki67, and MMP9 in the tumor tissues of mice inoculated with Huh7 cells co-cultured with exosomes from hypoxia-induced HepG2 cells significantly increased (p = 0.005, p < 0.001, p = 0.003, Fig. 3E) when compared to that in the control group. Here, MMP9 is linked to neoplasm.