Compared with that in the control group, the expression of lncRNA-PVT1 and FoxM1 was significantly upregulated in the tumor tissues of mice inoculated with Huh7 cells co-cultured with exosomes from hypoxia-induced HepG2 cells (p = 0.018 and p < 0.001, respectively). The gene discussed is PVT1; the disease is neoplasm.