After co-culture with exosomes from HepG2 HCC cells subjected to hypoxia (HepG2-hypoxia), E-cadherin expression in Huh7 cells was downregulated compared to that in untreated Huh7 cells, whereas N-cadherin and vimentin expression was significantly upregulated (p < 0.001). This evidence concerns the gene CDH1 and hepatocellular carcinoma.