Some lnRNAs also have been reported to exhibit tumor suppressor function, for example, lnRNA, Disrupted In Renal Carcinoma 3 (DIRC3), has been reported to act as a melanoma tumor suppressor, by acting locally to block SRY-box transcription factor 10(SOX10) chromatin binding at melanoma regulatory elements and activate Insulin-like growth factor binding protein 5 (IGFBP5) expression, a tumor suppressor, thereby inhibits the proliferation of melanoma cells [56]. The gene discussed is IGFBP5; the disease is melanoma.