A variety of TSG & oncogenes have been reported to be involved in a wide range of cancers like lung, breast, Hepatocellular carcinoma (HCC), etc., e.g., K-Ras, Catenin beta 1 (CTNNB 1), B-cell lymphoma/lymphoma 2 (BCL2), Phosphatase and tensin homolog (PTEN), p53, RB, etc. [48–50]. Here, RB1 is linked to hepatocellular carcinoma.