Additionally, cancer cell-derived EVs containing interferon gamma receptor 1 (IFNGR1), enhance PD-L1 expression on lymph node fibroblastic reticular cells (FRCs) through JAK1-STAT1 activation, resulting in CD8+ T cell depletion and potentially promoting lymph node metastasis of HNSCC [82]. Here, CD8A is linked to head and neck squamous cell carcinoma.