In HPV-positive tumor cells, induction of CXCL13 in CD4+ T cells lead to increased secretion of IFN-γ, which contributes to elevated tumor-infiltrating lymphocyte (TIL) counts and improved immune cell infiltration, thereby enhancing the prognosis of HNSCC patients [116,117]. The gene discussed is CD4; the disease is head and neck squamous cell carcinoma.