By contrast, ERβ knockout in male (6/9, 67%) or female (3/13, 23%) mice resulted in an insignificantly (p = 0.206) or significantly (p = 0.017) lower incidence of bladder cancer, compared with wild-type males (8/8, 100%) or females (9/12, 75%), respectively. The gene discussed is ESR2; the disease is urinary bladder cancer.