Immunohistochemistry in bladder cancer specimens (n = 61) showed that ERRα expression was significantly more often detected in high-grade tumors, higher stage (i.e., stages II–IV) cases, or those with distant metastasis and was associated with significantly worse overall survival, as an independent prognosticator (hazard ratio 4.15, p = 0.015). Here, ESRRA is linked to urinary bladder carcinoma.