NOTCH3 and breast cancer: Moreover, inhibitors of DLL4 like HB-32 and H3L2 have shown significant efficacy in inhibiting solid tumors in breast cancer research [53] Additionally, studies have linked JAG1 expression to vessel numbers in tumors, and interactions between JAG1/Notch3 and VEGF may play a role in angiogenesis in triple-negative breast cancer [54,55].