In particular, we have elucidated the mechanisms by which metal ions regulate tumor immune statutes, including Mn2+ activation of the cGAS–STING pathway, K+ activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, Pt-induced ICD and Ca2+-induced cellular pyroptosis. The gene discussed is CGAS; the disease is neoplasm.