CGAS and cancer: The cGAS–STING pathway, a key component of innate immunity, holds significant potential to enhance cancer immunotherapy A series of recent studies have found that the cGAS–STING pathway, which senses cytoplasmic DNA within (paracrine) macrophages and dendritic cells (DC) in tumor tissues, can be activated by tumor cell-derived DNA to promote the maturation of antigen-presenting cells, which in turn deliver tumor-specific antigens to T cells and play a crucial role in resurrecting the body's anti-tumor immune response.49