For example, Zhaohui Wang's team constructed a precise pH-responsive, TME-targeted nanoparticles (PMM NPs) encapsulating the TLR4 agonist Mpla and the STING agonist tetramanganese tetroxide NPs for the spatiotemporal orchestration of synergistic innate stimuli for anti-cancer immunotherapy.194. This evidence concerns the gene STING1 and cancer.