It was shown that CuS-RNP@PEI nanoparticle treatment could effectively deplete PTPN2, leading to the enrichment of intratumoral infiltrated CD8+ T-lymphocytes in loaded mice, as well as upregulation of the expression levels of IFN-γ and TNF-α in tumor tissues, which made the tumors more sensitive to immunotherapy. The gene discussed is IFNG; the disease is neoplasm.