Higher Abeta aggregation and pTau seen in AD organoids compared to WTDecreased MAP2 levels in infected organoidsAccelerated levels of AB in ZIKV-infected AD brain organoidsHigher BACE levels in AD models compared to WTp-Tau and p-GSK3a/B (Y216/Y279) increased in AD organoids compared to WTLevels of p-PERK and p-eIF2α were higher in AD organoids compared to WT organoidsPERKi treatment downregulated both Aβ and p-Tau expression in ZIKV-infected AD organoidslevel of Aβ production in ZIKV-infected WT organoids was increased compared to mock. The gene discussed is EIF2AK3; the disease is Alzheimer disease.