MAPT and Alzheimer disease: These models, derived from hiPSCs (Figure 2), have been instrumental in studying hallmark AD pathologies, such as the progressive accumulation of amyloidogenic amyloid-beta (Aβ) peptides and amyloid plaques, and tau hyperphosphorylation leading to neurofibrillary tangles (Dong et al., 2020; Kitahara et al., 2020; Esmail and Danter, 2021).