One-way ANOVA revealed significant effects of TMT injection and naringenin treatment on the hippocampal levels of AChE activity (F4, 30 = 6.93, p < 0.001) (Figure 5A) and AD-associated biomarkers, including p-Tau (F4, 30 = 7.546, p < 0.001) (Figure 5B), Aβ (F4, 30 = 7.703, p < 0.001) (Figure 5C), and presenilin 1 (F4, 30 = 5.985, p < 0.001) (Figure 5D). This evidence concerns the gene PSEN1 and Alzheimer disease.