A detailed review on navigating the Usher Syndrome genetic landscape by Micol B et al., indicate that patients with PCDH15 mutations are significantly less likely to have a “Positive” outcome, as only 3/12 cases were reported to acquire good or excellent CI performance for this gene, underscoring a potential link between PCDH15 gene and unfavorable outcomes (Liu et al., 2008; Brownstein et al., 2004; Wu et al., 2015; Grillet et al., 2009; Busi and Castiglione, 2024). Here, PCDH15 is linked to Usher syndrome.