NEFL and behavioral variant of frontotemporal dementia: Studies independent from the cohorts included in our multicentre study, although containing both genetic and sporadic bvFTD cases, showed in agreement with our findings that blood-based NfL can discriminate between bvFTD and PPD with sensitivities ranging from 70% to 88% and specificities ranging from 85% to 93%, respectively.18 20 21 In our study, we identified an optimal cut-off for NfL at 25.9 pg/mL, demonstrating a sensitivity of 65% and specificity of 96%.