Adipocytokines are immunomodulatory proteins secreted by adipocytes that act in feedback loops linking obesity and cardiometabolic disease, which typically include leptin, adiponectin, interleukin (IL)-6, IL-18, and tumor necrosis factor-alpha (TNF-a) (2). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.