(54) used leptin receptor-deficient mice (db/db) to find that fibroblasts expand during the process of periodontitis in type 2 diabetic mice, with significant upregulation of the IL-17 receptors Il17ra and Il17rc, the IL-1β receptor IL1R1, and the neutrophil chemokines CXCL1, CXCL5, CXCL10, and CXCL12. This evidence concerns the gene CXCL1 and periodontitis.