(74) demonstrated that signaling lymphocytic activation molecule family member 7 (SLAMF7) a receptor associated with macrophage hyperactivation in RA, and confirmed the presence of a SLAMF7 hyperactivated macrophage population in the synovial fluid of seropositive RA patients and in the lung tissue of COVID-19 patients. The gene discussed is SLAMF7; the disease is COVID-19.